Autotaxin Inhibitor

Autotaxin Inhibitors (26):

Cat. No.	Product Name	Effect	Purity

HY-101772

Ziritaxestat	Inhibitor	99.93%
Ziritaxestat (GLPG1690) is a first-in-class autotaxin (ATX) inhibitor, with an IC₅₀ of 131 nM and a K_i of 15 nM.

HY-13344

PF-8380	Inhibitor	99.04%
PF-8380 is a potent autotaxin inhibitor with an IC₅₀ of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.

HY-19329

HA130	Inhibitor	99.46%
HA130 is a selective autotaxin (ATX) inhibitor with an IC₅₀ of 28 nM.

HY-124772

BI-2545	Inhibitor	99.77%
BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC₅₀s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively.

HY-145344

ONO-8430506	Inhibitor	99.68%
ONO-8430506 is an orally bioavailable and potent autotaxin (ATX)/ENPP2 inhibitor with the IC₉₀ of 100 nM for ATX activity in mouse plasma.

HY-107781

PAT-505	Inhibitor	99.47%
PAT-505 is a potent, selective, noncompetitive and orally available autotaxin inhibitor, with an IC₅₀ of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma.

HY-135053

Autotaxin-IN-3	Inhibitor	98.24%
Autotaxin-IN-3 is a Autotaxin(ATX) inhibitor with an IC₅₀ of 2.4 nM, compound 33, sourced from patent WO2018212534A1.

HY-133019

ATX inhibitor 5	Inhibitor	99.20%
ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC₅₀ of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently.

HY-13344A

PF-8380 hydrochloride	Inhibitor	98.59%
PF-8380 hydrochloride is a potent autotaxin inhibitor with an IC₅₀ of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.

HY-103267

S32826 disodium	Inhibitor	98.85%
S32826 disodium is a potent autotaxin inhibitor, with an IC₅₀ of 8.8 nM. S32826 disodium shows similar inhibitory effects at various autotaxin isoforms (α, β and γ). S32826 disodium inhibits LPA release from adipocytes.

HY-135088

Autotaxin-IN-4	Inhibitor
Autotaxin-IN-4 (compound 51), extracted from patent WO2018212534A1, is an Autotaxin inhibitor. Autotaxin-IN-4 has the potential to treat idiopathic pulmonary fibrosis.

HY-103267A

S32826	Inhibitor
S32826 is a potent autotaxin inhibitor, with an IC₅₀ of 8.8 nM. S32826 shows similar inhibitory effects at various autotaxin isoforms (α, β and γ). S32826 inhibits LPA release from adipocytes.

HY-146205

ATX inhibitor 18	Inhibitor
ATX inhibitor 18 is a potent ATX inhibitor with an IC₅₀ value of 24.2 nM. ATX inhibitor 18 shows antiproliferative activity and anti-fibrosis activity. ATX inhibitor 18 suppresses collagen deposition in TGF-β-mediated cardiac fibrosis.

HY-146123

ATX inhibitor 20	Inhibitor
ATX inhibitor 20 (compound 24) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 2.3 nM.

HY-143420

ATX inhibitor 15	Inhibitor
ATX inhibitor 15 (compound 30), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC₅₀ of 2.17 nM. ATX inhibitor 15 inhibits in vivo ATX and the gene expression of pro-fibrotic factors. ATX inhibitor 15 has lung protection effects in Bleomycin challenged mice lung fibrosis model.

HY-144743

ATX inhibitor 12	Inhibitor
ATX inhibitor 12 (compound 20) is an orally active and potent ATX (autotaxin) inhibitor, with an IC₅₀ of 1.72 nM. ATX inhibitor 12 effectively alleviates lung structural damage with fewer fibrotic lesions at an oral dose of 60 mg/kg in C57Bl/6J mice. ATX inhibitor 12 can be uesd for idiopathic pulmonary fibrosis (IPF) research.

HY-146122

ATX inhibitor 19	Inhibitor
ATX inhibitor 19 (compound 22) is a potent ATX (autotaxin) inhibitor, with an IC₅₀ of 156 nM.

HY-143419

ATX inhibitor 14	Inhibitor
ATX inhibitor 14 (compound 4), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC₅₀ of 0.41 nM. ATX inhibitor 14 has the potential for fibrosis relevant diseases research.

HY-123637

Autotaxin-IN-1	Inhibitor
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC₅₀=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain.

HY-143581

ATX inhibitor 8	Inhibitor
ATX inhibitor 8 is a Autotaxin (ATX) inhibitor extracted from patent WO2018212534A1 compound 96.

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